Compyle allows users to execute a restricted subset of Python (almost similar to C) on a variety of HPC platforms. Currently we support multi-core CPU execution using Cython, and for GPU devices we use OpenCL or CUDA. Users start with code implemented in a very restricted Python syntax, this code is then automatically transpiled, compiled and executed to run on either one CPU core, or multiple CPU cores (via OpenMP) or on a GPU. Compyle offers source-to-source transpilation, making it a very convenient tool for writing HPC libraries. Some simple yet powerful parallel utilities are provided which can allow you to solve a remarkably large number of interesting HPC problems. Compyle also features JIT transpilation making it easy to us